Journal Scan Summary
Do genetic factors predispose to lone atrial fibrillation (AF)?
In this population-based study, Danish registry data were used to gather information on approximately 4 million residents born in Denmark in 1950 or later who had ≥1 relative.
A diagnosis of lone AF was identified before the age of 60 years in 9,507 individuals. Individuals who had ≥1 first-degree relative with lone AF were 3.5 times more likely to develop lone AF than individuals without a family history of lone AF. The odds of developing lone AF were approximately sixfold higher in individuals who had ≥2 first-degree relatives with lone AF.
The risk of developing lone AF before the age of 60 years is 3.5-fold higher when first-degree relatives have lone AF, and approximately sixfold higher when ≥2 first-degree relatives have lone AF.
The results are consistent with AF being caused by a gene mutation in at least some patients with idiopathic AF. However, another possible explanation for the findings is a behavioral or environmental factor that predisposes to AF and that could have familial clustering, such as obesity, excessive alcohol intake, or intense exercise.
Fred Morady, M.D., F.A.C.C. (Disclosure)
Arrhythmias, Afib, Cardiac Rhythm Management